Select an insecticide
Select one of the good quality insecticides with qualities to kill bees. Go through all its instructions carefully to get a clear idea how to use it. Also, purchase a projectile to get to the hive in the tree easily.
Finalize operation timing
Make sure to operate and destroy beehive is the late afternoon as you can find majority of them in the hive (and not overly aggressive).
Approach the beehive and spray
Carefully approach the beehive and spray the insecticide into the entrance. Now cover the opening of the hive with a used towel or a piece of thick cloth in order to keep the insecticide trapped inside the hive until all of them die.
Wait for the response
Wait for some time, may be overnight, and observe the bee activities. If you find bees flying around, then go through the same process again until you destroy all of them completely. However, if you do not observe any bee activities, put the beehive down with the help of a large stick or the handle of a broom.