Layer the Tissues
The first step is to create stacks of tissue paper of the same colour. Make sure that it is reasonably thick - six to eight tissues stacked on top of one another should be fine.
Give them a fold of approximately one inch before folding them again in the alternate direction. Keep making this pattern until the whole tissue is folded. Hold it from the bottom and fold the opposing ends. The tissues should now loosely be looking like a flower. Hold them carefully so that they do not open up.
Use the Wire
Now run the wire that you have through the central point from where you are gripping the tissues. Make sure that you do not damage the tissues. It will be much like threading a needle only in this case it is a semi finished tissue flower and the thread is actually a wire.
Staple the Flower
In order to hold it in place for a longer period of time, staple the part of the flower which is just above where the wire is passing through. Make sure that you use a large stapler, in order to make sure that the pin can hold the flower. Smaller staples generally cannot hold stacks of tissue paper.
Form a Bouquet
Make more flowers in a similar manner, using different coloured tissue paper. Once you have made a bunch, you can tie them together to form a colouful bouquet.