Educate yourself about the individual attacks and combinations of all the Devil May Cry 4 combos. For making a character attack an opponent, you will need to open the ‘Pause’ menu, view the necessary combo sequence and them make the character execute the combo by pressing the right combination of keys or buttons.
The best way to avoid being attacked by an opponent is to keep moving. It will be easier for the enemies to strike if your character is standing still while engaged in a fight. Similarly, it is best not to shoot at enemies that can fire projectiles back at you while you are in the air. This is because firing momentarily freezes you and thus leaves you more vulnerable to a projectile attack.
You would need to be ready at all times to side-roll away, should enemies start swarming you. It is much easier to avoid an attack using the side-roll away technique and if done properly, it can help avoid damage.
Instead of targeting enemies one by one, it is better to try and defend against the most pressing of threats. You will find yourself in trouble if you get distracted trying to kill one enemy before engaging another. You will need to shoot each enemy quite a few times before an enemy can be killed. For this reason, it would be best to start with the closest enemy.
Enemies would be hurt more effectively if you throw them either into the air or away from one another. Throwing an enemy against another would hurt both enemies.
Style rank in Devil May Cry 4 is something any player would want to keep at a fairly high level. This can be accomplished by performing as many attacks unique attacks as possible and not breaking the attack chain between enemies.
Collect as many orbs as possible by smashing everything you come across. The in-game collectibles give health etc.