Top 10 Most Painful Diseases in the World

There are thousands of known diseases which plague human beings on the face of earth. From birth until death, almost every person has to spend a certain period of illness which can either be due to a minor disease such as flu, fever etc. or due to a major disease such as cancer, shingles etc. It is understandable that each disease has a certain degree of pain which the patient has to suffer. Some diseases cause only small amounts of pain while some can be painful to the extent of becoming unbearable.


  • 1


    Cancer is the most painful of known diseases. One or more organs inside the human body develop a tumour which eventually causes the organ to fail completely. In severe cases, nerves get tangled up with the tumour, becoming the cause of severe pain.

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  • 2


    Appendix, which is a ‘Vestigial’ organ, is found in men and is an extension of the large intestine. Swelling in the Appendix can cause excruciating pain and can prove fatal if not treated in time.

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  • 3

    Heart attack

    Heart failure can be extremely painful and is fatal most of the times. Extreme pain in the left arm and chest are common symptoms of an impending heart attack.

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  • 4

    Trigeminal neuralgia

    Common symptoms of trigeminal neuralgia are extreme pain in the jaw, lip movements, eyes, forehead, scalp etc. The pain can be so excruciating that the victim can not even eat or brush properly.

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  • 5


    Shingles is a viral disease, mainly found in men. Upper arms, back, shoulders, neck and the victim’s face develop red boils which are very painful.

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  • 6

    Tooth abscess

    Tooth abscess is caused when a person neglects oral hygienic measures. A pulpy abscess develops in the mouth of the patient which is further linked to nerves inside the mouth. Pus in the abscess is very painful.

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  • 7

    Kidney stones

    Small stones develop inside kidneys due to long term consumption of impure water with high content of insoluble particles. These particles deposit in the kidneys and form a small stone. Kidney stones can cause excruciating pain.

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  • 8


    Arthritis is a disease which commonly occurs in elder people. Joints all over the body develop a swelling and even start to bend in severe cases.

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  • 9


    Dysmenorrhea is strictly related to women and can be very painful due to excessive bleeding, numbness and sweating during menses.

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  • 10

    Mouth Ulcers

    Mouth ulcers are blisters in the mouth which can develop for a number of different reasons. Ulcers make it impossible for the patient to eat properly.

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